Global Organ Preservation Market 2024–2033

Reports Description

As per the current market research conducted by the CMI Team, the global Organ Preservation Market is expected to record a CAGR of 7.2% from 2024 to 2033. In 2024, the market size is projected to reach a valuation of USD 306.7 Million. By 2033, the valuation is anticipated to reach USD 573.4 Million.

Organ People are Waiting For (As of September 2023)

Source: According to Organ Donar Gov.

The organ preservation market involves the development, manufacturing, and distribution of technologies, solutions, and devices aimed at maintaining the viability of organs intended for transplantation. This includes methods such as static cold storage and machine perfusion, which preserve organs by regulating temperature, oxygenation, and nutrient delivery.

Key players in the market innovate to improve preservation outcomes, enhance organ transportation, and extend organ viability. With the increasing demand for organ transplants globally, driven by factors like the rising prevalence of chronic diseases and advancements in surgical techniques, the organ preservation market plays a crucial role in facilitating successful organ transplantation procedures.

Organ Preservation Market – Significant Growth Factors

The Organ Preservation Market presents significant growth opportunities due to several factors:

• Increasing Demand for Organ Transplants: The rising prevalence of end-stage organ failure and chronic diseases drives the demand for organ transplants, consequently boosting the need for effective preservation methods and technologies.

• Advancements in Preservation Techniques: Continuous innovations in organ preservation technologies, such as normothermic and hypothermic machine perfusion, improve organ viability and transplant outcomes, encouraging their adoption and driving market growth.

• Growing Organ Donation Networks: Efforts to expand organ donation networks, coupled with initiatives to optimize organ procurement and allocation processes, contribute to higher availability of donor organs, driving the demand for preservation solutions.

• Rising Healthcare Expenditure and Research Investments: Increasing healthcare expenditure, coupled with investments in research and development activities focused on improving organ preservation techniques, stimulate market growth by fostering innovation and technological advancements in the field.

• Technological Advancements and Product Innovation: Opportunities exist for companies to develop innovative preservation solutions and devices, leveraging advancements in technology such as artificial intelligence, robotics, and bioengineering to enhance organ preservation outcomes and address unmet needs in the market.

Organ Preservation Market – Mergers and Acquisitions

The Organ Preservation Market has seen several mergers and acquisitions in recent years, with companies seeking to expand their market presence and leverage synergies to improve their product offerings and profitability. Some notable examples of mergers and acquisitions in the Organ Preservation Market include:

• In 2022, XVIVO Perfusion’s partnership with Contatti Medical in Brazil expands it’s business and grants access to a robust network of transplantation centers in Brazil, Latin America’s largest country. This strategic move facilitates market expansion and strengthens XVIVO’s presence in the region.

• In 2021, TransMedics obtained premarket approval from the FDA for its OCS Heart System to be utilized with organs from donors after brain death (DBD). This regulatory milestone allows TransMedics to expand its market reach and offer its advanced organ preservation system for DBD donors.

These mergers and acquisitions have helped companies expand their product offerings, improve their market presence, and capitalize on growth opportunities in the Organ Preservation Market. The trend is expected to continue as companies seek a competitive edge in the market.

COMPARATIVE ANALYSIS OF THE RELATED MARKET

Organ Preservation Market – Significant Threats

The Organ Preservation Market faces several significant threats that could impact its growth and profitability in the future. Some of these threats include:

• Regulatory Challenges and Compliance Issues: Stringent regulatory requirements and compliance standards governing organ preservation products can pose significant challenges to market players. Non-compliance with regulatory guidelines, including those related to product safety, efficacy, and quality assurance, may lead to delays in product approvals, recalls, or even fines, negatively impacting market growth and reputation.

• Limited Organ Availability: Despite efforts to expand organ donation networks, the persistent gap between the supply and demand for transplantable organs remains a significant threat to the organ preservation market. Limited organ availability, particularly for critical organs like hearts and lungs, can hinder market growth by constraining the potential pool of organs for preservation and transplantation.

• High Cost of Advanced Preservation Technologies: Advanced organ preservation techniques, such as normothermic machine perfusion, often involve substantial upfront costs for equipment, consumables, and maintenance. The high cost of adopting and implementing these technologies can act as a barrier to market entry for healthcare facilities, particularly in resource-constrained settings, limiting the widespread adoption of advanced preservation methods and constraining market growth.

• Risk of Organ Rejection and Transplant Complications: Despite advances in organ preservation techniques, the risk of organ rejection and transplant-related complications remains a significant concern. Factors such as ischemia-reperfusion injury, immunological mismatch, and infection can compromise transplant outcomes, leading to graft failure and patient morbidity.

Category-Wise Insights:

By Type

• Static Cold Storage (SCS): SCS involves storing organs at low temperatures to slow metabolic processes. While it’s a traditional method, trends show a gradual shift towards more advanced perfusion techniques due to limitations in preserving marginal donor organs and the desire for better outcomes in transplantation.

• Hypothermic Machine Perfusion (HMP): HMP utilizes cold perfusion solutions and machine-based circulation to preserve organs, allowing for better assessment and optimization of organ viability. This method is gaining traction due to its ability to improve preservation outcomes, particularly for marginal organs, and enhance transplant success rates.

• Normothermic Machine Perfusion (NMP): NMP maintains organs at near-physiological conditions, mimicking the body’s environment to sustain organ function. This emerging technique offers potential benefits such as reduced ischemia-reperfusion injury and improved organ quality, driving interest and investment in its development and adoption within the organ preservation market.

• Others: This category encompasses emerging preservation techniques, such as oxygenated hypothermic perfusion and sub normothermic perfusion, as well as cryopreservation methods. These innovative approaches aim to address specific challenges in organ preservation, such as extending preservation times and preserving complex organs, contributing to the diversification and advancement of the organ preservation market.

By Organ

• Kidney: Kidney preservation involves maintaining organ viability before transplantation. Trends include the adoption of hypothermic and normothermic machine perfusion techniques, advancements in preservation solutions, and the growing emphasis on ex vivo assessment to improve transplant outcomes.

• Liver: Liver preservation aims to maintain organ viability during storage and transportation. Trends include the utilization of machine perfusion methods, the development of preservation solutions with enhanced protective properties, and the integration of normothermic perfusion for improved preservation outcomes.

• Heart: Heart preservation focuses on maintaining myocardial function pre-transplantation. Trends include the use of machine perfusion technologies like the Organ Care System, advancements in preservation solutions to minimize ischemic injury, and research on ex vivo heart assessment techniques to enhance transplant success rates.

• Lung: Lung preservation involves techniques to preserve pulmonary function before transplantation. Trends include the adoption of ex vivo lung perfusion (EVLP) systems for evaluation and reconditioning of marginal donor lungs, advancements in cold storage solutions, and research on normothermic lung perfusion for extended preservation.

• Others (Pancreas, Intestine, etc.): Preservation of other organs like the pancreas and intestine focuses on maintaining viability and function before transplantation. Trends include the development of specialized preservation solutions tailored to each organ’s unique requirements, advancements in machine perfusion techniques, and research on novel preservation strategies to address specific challenges.

By Preservation Solution

• Intracellular Solutions: Intracellular solutions are preservation solutions designed to maintain cellular integrity by replenishing intracellular electrolytes and nutrients. Trends include the development of customized formulations tailored to specific organ types and advancements in additives to mitigate cellular damage during preservation, driving improved organ viability and transplant outcomes.

• Extracellular Solutions: Extracellular solutions maintain organ viability by preserving the extracellular matrix and preventing edema. Trends include the adoption of specialized formulations with optimized osmolarity and pH levels, along with the integration of antioxidants and anti-inflammatory agents to minimize ischemia-reperfusion injury and enhance organ preservation efficacy.

• Colloids: Colloids are preservation solutions containing suspended particles to maintain oncotic pressure and prevent cell swelling. Trends involve the exploration of novel colloid-based formulations with enhanced biocompatibility and stability, as well as the integration of nanoparticles for targeted drug delivery and tissue-specific preservation, driving advancements in organ preservation techniques.

• Others: Trends include the utilization of cryoprotectants, antioxidants, and metabolic modulators to enhance organ preservation outcomes, as well as the development of oxygen carriers and perfusates for normothermic machine perfusion, driving innovation in organ preservation strategies.

By End User

• Hospitals: Hospitals are key end-users of organ preservation solutions, employing them to maintain organ viability before transplantation surgeries. Trends include increasing adoption of normothermic machine perfusion, enhancing organ preservation outcomes, and improving patient outcomes through advanced preservation techniques.

• Organ Banks: Organ banks store and distribute organs for transplantation. Trends include the implementation of sophisticated preservation methods like hypothermic machine perfusion, optimizing organ viability during storage, and facilitating timely organ allocation to transplant centers.

• Tissue Banks: Tissue banks preserve and distribute human tissues for various medical procedures. Trends include the adoption of cryopreservation techniques, extending the shelf life of tissues, and expanding the range of transplantable tissues to meet the growing demand in reconstructive surgeries and regenerative medicine.

• Others: This category includes research institutes, biotechnology companies, and academic institutions utilizing organ preservation solutions for experimental purposes. Trends include the development of novel preservation technologies, such as ex vivo organ culture systems, to support research advancements in transplantation immunology, tissue engineering, and regenerative medicine.

Report Scope

Organ Preservation Market – Regional Analysis

The Organ Preservation Market is segmented into various regions, including North America, Europe, Asia-Pacific, and LAMEA. Here is a brief overview of each region:

• North America: In North America, a trend observed is the increasing adoption of normothermic machine perfusion techniques in organ preservation, driven by the region’s advanced healthcare infrastructure and high demand for transplantable organs. Additionally, there’s a growing emphasis on research and development to enhance preservation outcomes, supported by significant investments in biomedical innovation.

• Europe: Europe showcases a trend towards the establishment of collaborative organ sharing networks and standardized preservation protocols across countries, aiming to optimize organ utilization and transplantation outcomes. Furthermore, there’s a focus on sustainability in organ preservation practices, with efforts to minimize the environmental footprint of preservation solutions and devices.

• Asia-Pacific: In the Asia-Pacific region, a notable trend is the rapid expansion of organ transplantation programs and infrastructure, particularly in emerging economies like China and India. This growth is accompanied by increasing investments in healthcare technology, driving the adoption of advanced preservation techniques and solutions to meet the rising demand for transplantable organs.

• LAMEA (Latin America, Middle East, and Africa): The LAMEA region exhibits a trend towards improving access to organ transplantation through the development of regional organ procurement and preservation networks. Efforts are focused on enhancing organ donation rates, optimizing transportation logistics, and implementing cost-effective preservation solutions to address healthcare disparities and increase transplant accessibility.

Competitive Landscape – Organ Preservation Market

The Organ Preservation Market is highly competitive, with a large number of manufacturers and retailers operating globally. Some of the key players in the market include:

• XVIVO Perfusion AB
• TransMedics Inc.
• Organ Recovery Systems Inc.
• Preservation Solutions Inc.
• Bridge to Life Ltd.
• Franz Köhler Chemie GmbH
• Paragonix Technologies Inc.
• BioLife Solutions Inc.
• Waters Medical Systems LLC
• XVIVO Perfusion Inc.
• OrganOx Limited
• Organ Assist B.V.
• Preservation Solutions Inc.
• 21st Century Medicine
• Transplant Biomedicals S.L.
• Others

These companies operate in the market through various strategies such as product innovation, mergers and acquisitions, and partnerships.

New players entering the organ preservation market with innovative solutions include Organ Assist B.V., focusing on portable normothermic perfusion devices, and Transplant Biomedicals S.L., specializing in advanced preservation solutions.

Dominant key players such as XVIVO Perfusion AB leverage their extensive R&D investments to pioneer normothermic perfusion technologies, establishing market leadership through product diversification and strategic acquisitions.

TransMedics, Inc. secures market dominance with its Organ Care System, offering portable organ perfusion solutions that enhance organ viability and transplantation outcomes, further solidifying its position in the industry.

The Organ Preservation Market is segmented as follows:

By Type

• Static Cold Storage (SCS)
• Hypothermic Machine Perfusion (HMP)
• Normothermic Machine Perfusion (NMP)
• Others

By Organ

• Kidney
• Liver
• Heart
• Lung
• Others

By Preservation Solution

• Intracellular Solutions
• Extracellular Solutions
• Colloids
• Others

By End User

• Hospitals
• Organ Banks
• Tissue Banks
• Others

Regional Coverage:

North America

• U.S.
• Canada
• Mexico
• Rest of North America

Europe

• Germany
• France
• U.K.
• Russia
• Italy
• Spain
• Netherlands
• Rest of Europe

Asia Pacific

• China
• Japan
• India
• New Zealand
• Australia
• South Korea
• Taiwan
• Rest of Asia Pacific

The Middle East & Africa

• Saudi Arabia
• UAE
• Egypt
• Kuwait
• South Africa
• Rest of the Middle East & Africa

Latin America

• Brazil
• Argentina
• Rest of Latin America