Global Gene Synthesis Market 2024–2033

Reports Description

As per the current market research conducted by CMI Team, the global Gene Synthesis market is expected to record a CAGR of 19% from 2023 to 2032. In 2022, the market size is projected to reach a valuation of USD 1,200 million. By 2032, the valuation is anticipated to reach USD 5,879 million.

The gene synthesis market is experiencing growth due to the widespread acceptance of advanced technologies in biological synthetic processes. DNA-based technologies drive the market by facilitating gene synthesis and expanding it.

Increased research and development efforts in gene synthesis, along with the utilization of genes for new drug and therapy development, fuel market growth. Furthermore, advancements in innovation and the production of long-term therapies, including targeted therapy, are expected to drive market growth in the foreseeable future.

The rising popularity of immunotherapy as a treatment option for chronic disorders, particularly for conditions like cancer and tumors, provides a promising outlook for the gene synthesis market’s expansion in the forecast period.

Gene Synthesis Market – Significant Growth Factors

The gene synthesis market is poised for significant growth due to several key factors:

• Decreasing Cost of DNA Synthesis: The cost of DNA synthesis has been declining steadily over the years. This cost reduction has made gene synthesis more accessible and affordable, leading to increased adoption and demand for gene synthesis services. Lower costs have enabled researchers and biotechnology companies to undertake larger-scale projects and explore a wider range of applications.

• Technological Advancements: The continuous development of advanced technologies in gene synthesis has greatly contributed to market growth. Innovations in enzymatic DNA synthesis techniques, DNA assembly methods, and high-throughput synthesis platforms have improved gene synthesis efficiency, accuracy, and speed. These advancements have made it easier to synthesize complex genes, optimize sequences, and customize DNA constructs for various research and industrial purposes.

• Research and Development: The growing focus on research and development activities in the field of gene synthesis has propelled market growth. Researchers are actively exploring the potential of synthetic genes for a wide range of applications, including drug discovery, agriculture, biofuels, and industrial biotechnology. The ability to synthesize genes allows for the creation of novel genetic constructs, functional analysis of genes, and the development of new therapeutic interventions.

• Rising Demand for Personalized Medicine: Personalized medicine, which involves tailoring medical treatments to individual patients based on their genetic information, is a significant driver for the gene synthesis market. Gene synthesis plays a crucial role in generating custom DNA constructs for diagnostics, genetic testing, and gene therapy. The increasing demand for personalized medicine, particularly in the field of oncology, is driving the need for gene synthesis services.

• Growing Applications in Industrial Biotechnology: The use of synthetic genes and DNA constructs in industrial biotechnology is expanding rapidly. Gene synthesis enables the production of enzymes, bio-based chemicals, and biofuels through engineered microorganisms. It also facilitates the development of sustainable agricultural practices and the creation of genetically modified organisms (GMOs) with desired traits. The wide-ranging applications of gene synthesis in industrial biotechnology are expected to fuel market growth.

Overall, the combination of decreasing costs, technological advancements, increased research and development efforts, the demand for personalized medicine, and the expanding applications in industrial biotechnology are significant growth factors driving the gene synthesis market.

Gene Synthesis Market – Mergers and Acquisitions

The gene synthesis market has witnessed significant mergers and acquisitions, which have played a crucial role in shaping its landscape. Here are some notable instances:

• Thermo Fisher Scientific and Life Technologies: In 2014, Thermo Fisher Scientific acquired Life Technologies, a leading provider of gene synthesis services and molecular biology reagents. This acquisition strengthened Thermo Fisher’s position in the gene synthesis market and expanded its portfolio of genetic analysis solutions.

• Eurofins Genomics and MWG-Biotech: In 2015, Eurofins Genomics, a subsidiary of Eurofins Scientific, acquired MWG-Biotech, a prominent player in the gene synthesis market. This acquisition enabled Eurofins Genomics to enhance its gene synthesis capabilities and broaden its service offerings.

• Twist Bioscience and GeneArt: In 2015, Twist Bioscience, a synthetic biology company, acquired the gene synthesis business of GeneArt, a division of Life Technologies. This strategic acquisition allowed Twist Bioscience to strengthen its position in the gene synthesis market and expand its customer base.

• GenScript and BlueHeron Biotech: In 2015, GenScript, a global biotechnology company, acquired BlueHeron Biotech, a leader in gene synthesis and gene assembly services. This acquisition bolstered GenScript’s gene synthesis capabilities and complemented its existing portfolio of life science services.

• Eurofins Scientific and GATC Biotech: In 2017, Eurofins Scientific, a multinational scientific testing company, acquired GATC Biotech, a pioneer in gene synthesis and sequencing services. This acquisition expanded Eurofins Scientific’s presence in the gene synthesis market and reinforced its position as a leading provider of genomic services.

COMPARATIVE ANALYSIS OF THE RELATED MARKET

Gene Synthesis Market – Significant Threats

While the gene synthesis market presents significant growth opportunities, there are also several threats that could impact its development. Here are some significant threats to consider:

• Regulatory Challenges: The gene synthesis market faces regulatory challenges due to concerns surrounding biosecurity and the potential misuse of synthesized genes. Governments and regulatory bodies may impose restrictions or stringent regulations on gene synthesis activities to prevent unauthorized access to dangerous genetic materials or the creation of harmful organisms. Such regulations can hinder market growth and increase compliance costs for companies operating in the gene synthesis industry.

• Ethical Considerations: The ability to synthesize genes raises ethical concerns related to the manipulation of genetic material. The potential for misuse or unethical applications of gene synthesis technology, such as the creation of genetically modified organisms (GMOs) or controversial human gene editing, could lead to public scrutiny, backlash, and regulatory interventions. Ethical considerations can pose challenges to the acceptance and widespread adoption of gene synthesis solutions.

• Intellectual Property Issues: Intellectual property disputes can arise in the gene synthesis market, especially regarding patented genes or genetic constructs. Companies involved in gene synthesis may face legal challenges if they inadvertently infringe upon existing patents. Such disputes can lead to legal battles, licensing restrictions, and financial implications that may hinder market growth and innovation.

• Competition and Price Pressure: The gene synthesis market is becoming increasingly competitive as more companies enter the industry. This heightened competition can lead to price pressure, where companies may need to reduce their pricing to remain competitive. Lower prices could impact profit margins and potentially hinder investments in research and development or technological advancements.

• Cybersecurity Risks: The digitization and automation of gene synthesis processes introduce cybersecurity risks. Unauthorized access or breaches of gene sequence databases, genetic information, or proprietary technologies could compromise data integrity, privacy, and confidentiality. Cybersecurity threats pose challenges to maintaining trust, protecting intellectual property, and ensuring the secure exchange of genetic information in the gene synthesis market.

Report Scope

Category-Wise Insights

By Method:

In 2023, solid-phase synthesis emerged as the dominant technology in the gene synthesis market, experiencing a substantial adoption rate in recent years. This segment accounted for approximately 40.56% of the market’s revenue share.

Solid-phase synthesis is a prominent method used in various research fields and applications, allowing for the creation of both modified and canonical nucleic acid polymers, including RNA and DNA.

Leading commercial gene synthesis services providers, such as Agilent Technology, Blue Heron Biotech, and Sloning BioTechnology, primarily utilize solid-phase synthesis processes. These companies leverage different synthesis platforms to offer their services in the market.

By Service:

In 2023, the antibody DNA synthesis segment commanded a significant market share of 60.90%. This dominance was facilitated by the presence of multiple market players offering services specifically for antibody DNA synthesis.

These companies cater to research institutions and biotech/pharma companies, enabling the cloning and synthesis of antibody chain sequences into various vectors. Twist Bioscience Corporation made an announcement in April 2022 regarding the introduction of a high-throughput antibody production platform.

This platform allows customers to convert digital DNA (dDNA) sequences into purified IgG antibodies through an antibody production workflow. Similarly, in June 2022, Codex DNA, Inc. showcased automated synthetic biology technologies at the conference on antibody engineering and therapeutics in Europe. These technologies were designed to accelerate discovery workflows.

By Application:

In 2023, the gene & cell therapy development segment emerged as the dominant sector within the gene synthesis market, capturing a substantial revenue share of 37.89%. This segment is expected to contribute to the expansion of advanced therapies, particularly for the treatment of chronic diseases.

Gene and cell therapies have gained significant recognition among developers due to their efficacy in addressing diseases that were previously untreatable using traditional treatment methods. To promote advancements in cell and gene therapies, various initiatives have been undertaken by biotechnology and pharmaceutical companies.

For instance, in January 2022, Century Therapeutics announced a collaboration with Bristol Myers Squibb Company to jointly develop allogeneic cell therapies derived from induced pluripotent stem cells (iPSCs). These collaborations and initiatives reflect the growing interest and investment in gene and cell therapy development, aiming to provide innovative treatment options for a wide range of diseases.

By End-use:

In 2022, academic and government research institutes emerged as the dominant players in the gene synthesis market in terms of revenue share. This dominance was primarily driven by the increased utilization of gene synthesis services in research settings.

The segment accounted for approximately 54.30% of the global revenue share in 2022. Research institutes are actively engaging in collaborations with service providers to accelerate their research programs that involve the synthesis and characterization of gene fragments.

For example, in February 2021, the Medicines Manufacturing and Innovation Centre partnered with Exactmer, Novartis, UK Research & Innovation, and AstraZeneca. The objective of this collaboration is to develop a sustainable, scalable, and cost-effective manufacturing process for oligonucleotides.

Gene Synthesis Market – Regional Analysis

The gene synthesis market exhibits regional variations in terms of market size, growth rate, and market dynamics. Here is a regional analysis of the gene synthesis market:

• North America: North America holds a significant share in the gene synthesis market. The presence of advanced healthcare infrastructure, a strong research ecosystem, and substantial investments in biotechnology and pharmaceutical industries contribute to the market’s growth in this region. The United States, in particular, is a major contributor to the gene synthesis market, driven by the presence of prominent market players, increased R&D activities, and a supportive regulatory environment.

• Europe: Europe is another key region in the gene synthesis market. Countries such as Germany, the United Kingdom, and France have well-established biotech and pharmaceutical sectors, which drive the demand for gene synthesis services. The region also benefits from extensive research collaborations and funding from government and private organizations, fostering advancements in gene synthesis technology and applications.

• Asia Pacific: The Asia Pacific region is experiencing rapid growth in the gene synthesis market. Factors such as the expanding biotechnology and pharmaceutical sectors, increasing research and development activities, and a large population base contribute to the market’s growth in this region. Countries like China, India, Japan, and South Korea are emerging as significant contributors to the gene synthesis market in the Asia Pacific region.

• Latin America: Latin America is witnessing steady growth in the gene synthesis market. The region’s improving healthcare infrastructure, rising investments in biotechnology and pharmaceutical industries, and growing awareness about advanced therapies contribute to market growth. Brazil, Mexico, and Argentina are among the key markets in Latin America.

• Middle East and Africa: The Middle East and Africa region are gradually embracing gene synthesis technologies. The market growth is driven by increasing investments in healthcare infrastructure, research collaborations with international partners, and a growing focus on precision medicine. Countries like the United Arab Emirates and South Africa are emerging as potential markets for gene synthesis in this region.

List of the prominent players in the Gene Synthesis Market:

• GenScript
• GenScript
• Brooks Automation Inc. (GENEWIZ)
• Boster Biological Technology
• Twist Bioscience
• ProteoGenix Inc
• Biomatik
• ProMab Biotechnologies Inc.
• Thermo Fisher Scientific Inc.
• Integrated DNA Technologies Inc.
• OriGene Technologies Inc.
• Others

The Gene Synthesis Market is segmented as follows:

By Method

• Solid-phase Synthesis
• Chip-based Synthesis
• PCR-based Enzyme Synthesis

By Services

• Antibody DNA Synthesis
• Viral DNA Synthesis
• Others

By Application

• Gene & Cell Therapy Development
• Vaccine Development
• Disease Diagnosis
• Others

By End-use

• Biotechnology & Pharmaceutical Companies
• Academic & Government Research Institutes
• Contract Research Organizations

By Region

North America

• U.S.
• Canada
• Mexico
• Rest of North America

Europe

• Germany
• France
• U.K.
• Italy
• Spain
• Rest of Europe

Asia Pacific

• China
• Japan
• India
• New Zealand
• Australia
• South Korea
• Rest of Asia Pacific

The Middle East & Africa

• Saudi Arabia
• UAE
• Egypt
• Kuwait
• South Africa
• Rest of the Middle East & Africa

Latin America

• Brazil
• Argentina
• Rest of Latin America