Global Dental Membrane and Bone Graft Substitute Market 2024–2033

Reports Description

As per the current market research conducted by the CMI Team, the global Dental Membrane And Bone Graft Substitute Market is expected to record a CAGR of 9.24% from 2024 to 2033. In 2024, the market size is projected to reach a valuation of USD 1,143.55 Million. By 2033, the valuation is anticipated to reach USD 2,533.3 Million.

Global Healthcare Expenditure

Source: OECD

The dental membrane and bone graft substitute market is a growing industry that provides materials and products used in dental bone regeneration procedures for patients affected by oral health disorders such as periodontal diseases and oral cancer. Dental membranes and bone graft substitutes are used alongside dental bone grafts to allow cell proliferation during the regeneration process.

Increasing healthcare expenditure is providing access to dental care services for individuals across the globe. This means more people have the opportunity to receive dental treatments, including procedures that may require dental membranes and bone graft substitutes. Greater access to dental care leads to higher demand for these products, driving market growth.

Dental Membrane and Bone Graft Substitute Market – Significant Growth Factors

The Dental Membrane and Bone Graft Substitute Market presents significant growth opportunities due to several factors:

• Increasing prevalence of dental disorders: The global rise in the incidence of dental disorders, particularly periodontal diseases and tooth loss, is a significant factor driving the demand for dental membrane and bone graft substitutes. For instance, according to the World Health Organization, oral diseases affect close to 3.5 billion people worldwide.

• Increasing use of bone grafts in dentistry: The increasing use of bone grafts in dentistry is a significant driver for the global dental membrane and bone graft substitute market. Bone grafts are used to promote bone growth and regeneration in various dental procedures, including dental implant placement, tooth extraction, facial trauma treatment, and reconstructive surgery of the mouth, face, and jaws.

• Growing demand for cosmetic dentistry: The growing popularity of dental implants for cosmetic purposes is driving the demand for dental membrane and bone graft substitutes. These materials are used to support the implant and promote bone growth, ensuring a natural-looking and functional smile. Rising celebrity as well as growing social media influence is leading to increased spending on cosmetic surgeries including correction of tooths and jaws.

• Growing awareness of oral health: One of the main factors driving the market for bone graft and dental membrane substitutes is the increased awareness of oral health. People are seeking cutting-edge dental procedures to address a variety of dental ailments as they become more conscious of how important it is to maintain good oral health. Due to the increased awareness, there is a greater need for bone graft replacements and dental membranes, which are necessary for periodontal defect regeneration, dental implant procedures, and other dental treatments.

• Increase in tooth loss and tooth decay: Nearly 3.5 billion individuals worldwide suffer from oral disorders, the most frequent of which are tooth decay and tooth loss. For instance, according to the World Health Organization, numerous causes, such as inadequate food, lack of access to dental care, and poor oral hygiene, are blamed for the rising prevalence of these disorders.

Dental Membrane and Bone Graft Substitute Market – Mergers and Acquisitions

The Dental Membrane and Bone Graft Substitute Market has seen several mergers and acquisitions in recent years, with companies seeking to expand their market presence and leverage synergies to improve their product offerings and profitability. Some notable examples of mergers and acquisitions in the Dental Membrane and Bone Graft Substitute Market include:

• In August 2022, Orthofix Medical Inc., a global medical device company specializing in spine and orthopedics, announced today a strategic partnership with CGBio, a developer of innovative synthetic bone grafts used clinically in Asia for spine, orthopedic, trauma, and dental applications. The collaboration aims to advance the clinical development and commercialization of Novosis™ recombinant human bone morphogenetic protein-2 (rhBMP-2) bone growth materials and other future tissue regenerative solutions in the U.S. and Canadian markets.

• In January 2021, Dentsply Sirona announced today the acquisition of Datum Dental, Ltd., an Israel-based company renowned for its innovative dental regeneration products, including the OSSIX® biomaterial portfolio and the clinically superior proprietary technology, GLYMATRIX®. This acquisition complements Dentsply Sirona’s existing implant dentistry strategy, which includes Ankylos, Astra Tech Implant System, Xive, and Atlantis, by emphasizing established quality and meaningful innovation.

• In December 2020, Collagen Matrix, Inc., a leading global provider of regenerative, collagen-based, xenograft-derived medical devices, acquired Sunstar’s Degradable Solutions division, including its GUIDOR-branded line of resorbable synthetic medical implants. This strategic acquisition strengthens Collagen Matrix’s position in the market and expands its portfolio of innovative, collagen-based solutions for various medical applications.

These mergers and acquisitions helped companies expand their product offerings, improve their market presence, and capitalize on growth opportunities in the dental membrane and bone graft substitute market. The trend is expected to continue as companies seek to gain a competitive edge in the market.

COMPARATIVE ANALYSIS OF THE RELATED MARKET

Dental Membrane and Bone Graft Substitute Market – Significant Threats

The dental membrane and bone graft substitute market face several significant threats that could impact its growth and profitability in the future. Some of these threats include:

• High cost of procedures and products: Advanced dental membranes and bone graft substitutes often come with high production costs, making them expensive for dental clinics and patients. The overall cost of dental procedures involving these products can be prohibitively high, limiting their adoption, especially in developing countries.

• High risk of infections and complications: Despite advancements in dental grafting techniques, the risk of infections and complications remains a significant concern that restrains market growth. Dental grafting procedures, like any surgical intervention, carry the potential for infections, which can lead to serious complications for patients.

• Limited reimbursement policies: Another major restraint on the market is the limited reimbursement policies for dental procedures involving advanced grafting techniques. In many regions, dental treatments are not fully covered by insurance plans, particularly those involving cutting-edge technologies and materials.

• Variability in Clinical Outcomes: The success of dental grafting procedures can vary due to numerous factors, including patient-specific conditions, differences in surgical techniques, and the quality of the graft materials used. This unpredictability can impact the perceived reliability of dental graft substitutes, making practitioners hesitant to adopt new products without consistent and proven results.

Category-Wise Insights:

By Product Type

• Dental Membrane: Dental membranes are crucial components in guided bone regeneration (GBR) and guided tissue regeneration (GTR) procedures. They act as barriers, preventing the invasion of surrounding soft tissues into the bone graft area, thus facilitating the growth of new bone.  Dental membranes create a space between the soft tissue (gum) and the bone defect, preventing the fast-growing gum tissue from filling the gap.

1. Resorbable Membrane: These membranes are designed to degrade naturally over time, eliminating the need for a second surgery for removal. They are often made from collagen or synthetic polymers.
2. Non-Resorbable Membranes: These membranes need to be surgically removed after some time. They are typically made of materials like titanium or expanded polytetrafluoroethylene (ePTFE).

• Bone Graft Substitutes: Bone graft substitutes are artificial, inorganic, or bio-organic materials used to promote bone growth and regeneration in dental and orthopedic procedures. They are designed to mimic the properties of natural bone tissue and are used to fill bone defects or gaps, allowing for the growth of new bone tissue.

1. Demineralized Bone Matrix: Demineralized Bone Matrix (DBM) is a type of bone graft substitute that is derived from human allograft through the removal of the mineralized component of bone through acid extraction.
2. Xenograft: Xenografts are derived from different species, such as bovine or porcine sources. These grafts offer a readily available supply and reduced morbidity compared to autografts. Xenografts undergo thorough processing to ensure compatibility and safety.
3. Allograft: Allografts are sourced from human donors, providing an alternative when autografts are not feasible. These grafts undergo extensive processing to ensure safety and reduce the risk of disease transmission. Allografts offer availability without the morbidity associated with donor site harvesting.
4. Autograft: Autografts involve harvesting bone from the patient’s own body, typically from the hip or other sites. These grafts are renowned for their high compatibility and lack of immune rejection risk.
5. Others: The other types of bone graft substitutes include synthetic bone grafts. These are man-made materials designed to mimic the properties of natural bone. They include materials like hydroxyapatite, beta-tricalcium phosphate (β-TCP), calcium sulfate, and bioactive glass.

By Material Type

• Hydrogel: Hydrogels are three-dimensional networks of hydrophilic polymers capable of retaining large amounts of water. They offer excellent biocompatibility and can be tailored to mimic the extracellular matrix, facilitating cell adhesion, migration, and proliferation. Hydrogels are used in dental membranes and bone graft substitutes to provide a scaffold for tissue regeneration, promoting wound healing and bone formation.

• Collagen: Collagen is a natural protein found abundantly in the extracellular matrix of connective tissues. Collagen-based membranes and graft substitutes are biocompatible and promote cell attachment and proliferation. They provide mechanical support and enhance the regeneration of soft and hard tissues in dental procedures. Collagen scaffolds can also serve as carriers for growth factors and bioactive molecules, further enhancing their regenerative potential.

• Polytetrafluoroethylene (PTFE): Polytetrafluoroethylene (PTFE) is a synthetic polymer known for its inertness, biocompatibility, and non-stick properties. PTFE-based membranes are commonly used in guided bone regeneration (GBR) procedures to create barriers that prevent soft tissue infiltration into the defect site while allowing for bone regeneration. These membranes provide stability and support during the healing process, facilitating successful bone augmentation.

• Human Cell Sources: Human cell sources, including mesenchymal stem cells (MSCs) and growth factors derived from autologous or allogeneic sources, play a crucial role in tissue engineering and regenerative medicine. These cells and growth factors are often incorporated into scaffolds or carriers to enhance tissue regeneration and accelerate healing in dental procedures. Human cell-based therapies offer the potential for personalized treatment approaches and improved clinical outcomes.

• Hydroxypatite (HA): Hydroxyapatite (HA) is a naturally occurring mineral form of calcium apatite found in bone tissue. HA-based bone graft substitutes closely resemble the composition of natural bone and provide an osteoconductive scaffold for new bone formation. HA particles or coatings enhance bone integration and stability, making them ideal for applications in dental implants, socket preservation, and periodontal regeneration.

• Tricalcium Phosphate (TCP): Tricalcium phosphate (TCP) is a biocompatible ceramic material widely used in bone graft substitutes due to its osteoconductivity and ability to support bone ingrowth. TCP scaffolds provide a porous structure that facilitates vascularization and cellular infiltration, promoting bone regeneration and integration with the surrounding tissues. TCP-based graft substitutes are suitable for various dental procedures, including ridge augmentation and sinus floor elevation.

• Others: The others category encompasses a range of additional materials used in dental membranes and bone graft substitutes, such as bioactive glasses, synthetic polymers, and composite materials. These materials offer diverse properties, including bioactivity, resorbability, and mechanical strength, catering to specific clinical needs and preferences. Researchers continue to explore novel materials and fabrication techniques to develop advanced biomaterials for enhanced tissue regeneration and improved outcomes in dental surgery.

By End Users

• Hospitals: Hospitals serve as primary centers for dental surgeries and complex procedures requiring specialized equipment and multidisciplinary care. They offer a wide range of dental services, including implant surgeries, periodontal treatments, and oral surgeries. Hospitals have the infrastructure and resources to handle diverse patient populations and cater to both routine and emergency dental procedures. Dental membranes and bone graft substitutes are commonly used in hospital settings for patients undergoing major dental surgeries or those with complex medical conditions.

• Dental Clinics: Dental clinics are dedicated facilities focused on providing preventive, diagnostic, and therapeutic dental care. These clinics are often operated by dentists or dental specialists and offer a range of services, from routine check-ups and cleanings to restorative procedures and oral surgeries. Dental membranes and bone graft substitutes are frequently utilized in dental clinics for various treatments, such as socket preservation, ridge augmentation, and periodontal regeneration. Dental clinics provide personalized care in a comfortable environment, catering to the specific needs of individual patients.

• Ambulatory Surgical Centers: Ambulatory surgical centers (ASCs) specialize in outpatient surgical procedures that do not require overnight hospitalization. These facilities offer a convenient and cost-effective alternative to traditional hospital settings, providing efficient surgical care in a dedicated outpatient setting. ASCs are equipped to perform a wide range of dental surgeries, including implant placements, bone grafting procedures, and soft tissue grafts. Dental membranes and bone graft substitutes are commonly used in ASCs for minimally invasive procedures aimed at promoting tissue regeneration and bone healing.

• Others: This category includes healthcare venues like academic dental institutes, research centres, and specialist clinics. Academic dentistry schools focus on education, research, and clinical practice, while research centres develop new dental products and methods. Specialty clinics provide advanced surgical care for complicated dental diseases, such as periodontal and oral surgery.

Report Scope

Dental Membrane and Bone Graft Substitute Market – Regional Analysis

The Dental Membrane and Bone Graft Substitute Market is segmented into various regions, including North America, Europe, Asia-Pacific, and LAMEA. Here is a brief overview of each region:

• North America: The North American region, comprising the United States and Canada, stands as a pivotal hub for the dental membrane and bone graft substitute market. The region benefits from advanced healthcare infrastructure, with well-established dental clinics and hospitals equipped with state-of-the-art facilities. High prevalence rates of dental disorders, including periodontal diseases and tooth loss, drive the demand for regenerative dental procedures, such as bone graft surgeries and dental implant placements.

• Europe: Europe emerges as a significant market for dental membrane and bone graft substitute products, driven by various factors unique to the region. Supportive government policies and reimbursement schemes for dental procedures encourage the adoption of advanced dental technologies and treatments. These factors, coupled with the presence of a robust healthcare infrastructure and a strong emphasis on education and research, propel the growth of the Dental Membrane and Bone Graft Substitute market in Europe.

• Asia-Pacific: The Asia Pacific region experiences robust growth in the dental membrane and bone graft substitute market, fuelled by several key factors. The burgeoning middle-class population, along with increasing disposable incomes, drives demand for dental treatments and aesthetic procedures, including dental implants and bone graft surgeries. Rising healthcare expenditure and investments in healthcare infrastructure across Asia Pacific countries further contribute to market expansion.

• LAMEA (Latin America, Middle East, and Africa): LAMEA represents a region of significant growth potential for the dental membrane and bone graft substitute market, driven by various socioeconomic and healthcare factors. Efforts to improve access to healthcare services in LAMEA countries contribute to the increasing demand for dental treatments, including implant surgeries and bone graft procedures. Governments and private sector investments in healthcare infrastructure and technology enhance the availability and quality of dental care services in the region.

Competitive Landscape – Dental Membrane and Bone Graft Substitute Market

The Dental Membrane and Bone Graft Substitute Market is highly competitive, with a large number of manufacturers and retailers operating globally. Some of the key players in the market include:

• ACE Surgical Supply Co. Inc.
• Biohorizons Inc.
• Botiss Biomaterials GmbH
• Collagen Matrix Inc.
• CURASAN AG
• Dentsply Sirona
• Geistlich Pharma Ag
• KLS Martin Group
• Lifenet Health
• Medtronic
• NovaBone Products LLC
• RTI Surgical Holdings Inc.
• Salvin Dental Specialities Inc.
• Straumann Group
• Zimmer Biomet
• Others

These companies operate in the market through various strategies such as product innovation, mergers and acquisitions, and partnerships.

New players entering the dental membrane and bone graft substitute market are adopting innovation and development to differentiate themselves and gain traction. These players often focus on unique sourcing strategies, such as innovation in the bone graft membrane, innovative manufacturing techniques, and cost-effective solutions.

Companies are developing combination products that integrate dental membranes and bone graft substitutes, simplifying surgical procedures and enhancing treatment outcomes. This strategy helps them increase their market share and customer base.

The Dental Membrane and Bone Graft Substitute Market is segmented as follows:

By Product Type

• Dental Membrane
  • Resorbable Membranes
  • Non-Resorbable Membranes
• Bone Graft Substitutes
  • Demineralized Bone Matrix
  • Xenograft
  • Allograft
  • Autograft
  • Others

By Material Type

• Hydrogel
• Collagen
• Polytetrafluoroethylene (PTFE)
• Human Cell Sources
• Hydroxypatite (HA)
• Tricalcium Phosphate (TCP)
• Others

By End Users

• Hospitals
• Dental Clinics
• Ambulatory Surgical Centers
• Others

Regional Coverage:

North America

• U.S.
• Canada
• Mexico
• Rest of North America

Europe

• Germany
• France
• U.K.
• Russia
• Italy
• Spain
• Netherlands
• Rest of Europe

Asia Pacific

• China
• Japan
• India
• New Zealand
• Australia
• South Korea
• Taiwan
• Rest of Asia Pacific

The Middle East & Africa

• Saudi Arabia
• UAE
• Egypt
• Kuwait
• South Africa
• Rest of the Middle East & Africa

Latin America

• Brazil
• Argentina
• Rest of Latin America